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Play Video about fusion biopsy

Fusion Biopsy – Overview

The prostate gland is a significant part of a man’s reproductive system. It helps with the production of the component of the semen. In this article, we will discuss the usage and accuracy of fusion biopsy to diagnose prostate cancer. A biopsy involves collecting or taking a sample from a suspected tissue with abnormal growth in the body with a biopsy needle.

Advancement in technology usage for investigating and diagnosing a health condition is the new order of the day—one of the significant advances in using modern technology such as guided fusion biopsy. The prostate cancer evaluation procedure has contributed positively to diagnosing prostate cancer.

A fusion biopsy procedure combines an MRI scan and ultrasound to give a clearer view of suspected abnormal cells in the prostate gland. In other words, it aids proper guiding of taking a sample from the suspected tissue with minimal side effects.

Advantages of fusion biopsy

The procedure uses one of the most advanced technologies to detect aggressive and non-aggressive cancerous cells in the prostate gland. However, using this procedure may mean less sample tissue will be needed for collection. The advantages include:

  • It helps to reduce the diagnosis of insignificant cancerous cells.
  • Bring about fewer false-negative results
  • It will help to reduce the number of unnecessary biopsies in the future
  • The procedure will help reduce the chances of high-risk cancerous cell
  • When you are an active surveillance patient, it will help promote calmness as you are confident of the effectiveness of this procedure.

However, experts suggest that fusion biopsy will help detect and accurately diagnose prostate cancer in its early stage.

Why your doctor may recommend fusion biopsy?

Some factors may point to abnormal cell growth in your body. However, abnormal cell growth in the prostate tissue could mean the presence of cancerous or noncancerous cells. When your prostate-specific antigen (PSA) is on the high side or keeps rising, your doctor may suspect the presence of an abnormally grown cell. They may advise you to go for a fusion biopsy procedure. Although, there are more than one reasons why your PSA level may keep increasing, and prostate cancer is one of them. But, do not panic until your doctor has carried out the necessary investigations and made a proper diagnosis.

Furthermore, reports indicate that over 700,000 men in America have an elevated PSA level. These men often undergo several biopsies to confirm the presence of cancerous cells. The usage of random sampling to detect cancerous cells may sometimes be inefficient. It can as well miss some significant cancerous cells in your prostate. Instead, your doctor may decide you go for a fusion biopsy procedure to confirm the significant cancerous cells missed by random sampling.

Undergoing a fusion biopsy will help your doctor (urologist) determine the specific area requiring sampling. The procedure will aid the guidance of the biopsy needle to the exact suspected tissue. The process will help reduce the number of repeated biopsies. It will also help provide the atmosphere for an early-stage treatment option.

Who is a candidate for fusion biopsy

Before your doctor certifies you as the right candidate for this procedure, you must meet specific criteria. One criterium is a report of an elevated prostate-specific antigen (PSA) level. Elevated PSA can serve as an excellent pointer to suspect cancerous cells. Furthermore, if your doctor notices an abnormal lump in your prostate area during a digital rectal exam (DRE), a prostate biopsy may be required for further evaluation.

Lastly, there are several types of biopsies. Suppose you have done the traditional ultrasound-guided biopsies, and your doctor disagrees with the negative result. There may be a concern about the presence of the cancerous cell. You may be asked to undergo a fusion biopsy for prostate cancer.

Differences between traditional biopsy and fusion biopsy

Often, the traditional examinations may give an uncertain result. Some types of conventional biopsies include Transrectal ultrasound (TRUS). The significant setback of these biopsies is that they may miss some cancerous cells or give an inconclusive report. Hence, there may be a need for a fusion biopsy to help correct all of these setbacks—prostate cancer’s specificity and detection rate increase when you undergo a fusion biopsy for possible cancerous cells.

Furthermore, the traditional biopsies may not reveal all of the abnormalities in the prostate gland. Scientists indicate that the risk of infection is high as you may require multiple biopsies, which is not the case with a fusion biopsy procedure. Experts often refer to TRUS as a blind sampling method. During TRUS, your doctor may miss some actual cancerous cells.

Lastly, a fusion biopsy will reveal a clearer image of the abnormal cells in tissues. This will aid in proper guiding of the biopsy needle to the target tissue for sample collection.

Possible side effect

Like every other form of biopsies, fusion biopsy has its side effect. Although, these effects are minimal when compared with a Transrectal ultrasound biopsy. However, the most familiar side effects are;

  • Traces of blood in your urine during the recovery stage
  • Minor or light bleeding from the rectum after the procedure
  • Blood traces in the semen
  • Minimized urinary tract infection
  • Traces of blood in the stool
  • Frequent urge to urinate

However, these common side effects can be challenging. But, they only last for a few days. Your doctor will have informed you of these after-procedure effects. But if they persist for more than two weeks, it is better to speak with your doctor for further clarification.

How does Fusion biopsy work?

The procedure is technology-driven. It usually involves a team of health professionals. Along with your urologist, a pathologist, a nurse, and a radiologist will join the health team. Since your doctor has certified you as the right candidate for this procedure, you might discuss the possible side effect to reduce panic. Your doctor will give you antibiotics and anesthesia to numb you and make the process painless.

Furthermore, your radiologist will use a magnetic resonance imaging (MRI) machine to take a 3-dimensional image of the prostate. This will aid a clearer view of the prostate gland and the target tissues. The urologist will perform the biopsy with an ultrasound guide using the MRI scan as a reference. However, the MRI images will be fused with real-time images from the ultrasound during the fusion biopsy procedure.

Combining these two images will increase accuracy and helps your urologist separate the healthy cells from the abnormal ones. Your doctor will carefully guide the biopsy needle into the target tissue to collect the sample. Since the images will be fused, your urologist will be able to carry out an accurate and precise sample collection. The sample collected will be given to a pathologist for viewing under the microscope.

Possible results after the procedure

Once the fusion biopsy is successful, your pathologist will take over the next step. The pathologist will place the sample under the microscope for viewing to conclude. Here, a description of the sample retrieved will be done. A description of the color and the consistency of the tissue might serve as the first clue. If the tissue is abnormal, your pathologist will note this. The pathologist will grade the development stage if the cells come out cancerous.

There is a possibility of aggressive and non-aggressive cancerous cells. The pathologist will conclude before your urologist gives a final diagnosis.

Is this procedure painful?

Biopsies involve using needles and devices. The procedure may make you slightly uncomfortable. But, the pain is usually reduced compared to other types of biopsies. Before commencing the process, your doctor will administer an anesthetic injection. You might not feel any pain during the procedure due to the anesthesia. But, you may feel a slight discomfort with the injection. As the biopsy needle finds its way into the targeted tissues, you may feel uncomfortable. Generally, this procedure will be painless when your urologist numbs you with IV injections.

The time frame for the recovery phase

Since this technological procedure gives a close to perfect result, there may be no need for further biopsy. This may mean that your recovery phase after undergoing this procedure will be fast. However, it may take up to a month to recover completely from the process. If you notice any change in body function, reach out to your doctor for immediate intervention.

Questions to ask your doctor

You might ask your doctor the following questions if you require more information before agreeing to carry out the procedure. A few of the questions include;

  1. What are the possibilities that the procedure will lead to a cancer diagnosis?
  2. What can I do to prevent or minimize the effect of complications after undergoing the procedure?
  3. In case you are using blood-thinning medications such as aspirin, ask if you should stop it or not
  4. What is the cost implication of fusion biopsy?


Generally, the procedure may take about 45minutes to 1hour, depending on the satisfaction of your urologist.

Researchers indicate that targeted fusion biopsies are better and more precise than the traditional TRUS biopsies.

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